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Enhanced solution representations for vehicle routing problems with split deliveries

《工程管理前沿（英文）》页码 483-498 doi: 10.1007/s42524-023-0259-z

摘要： In this study, we investigate a forest-based solution representation for split delivery vehicle routing problems (SDVRPs), which have several practical applications and are among the most difficult vehicle routing problems. The new solution representation fully reflects the nature of split delivery, and can help reduce the search space when used in heuristic algorithms. Based on the forest structure, we devise three neighborhood search operators. To highlight the effectiveness of this solution representation, we integrate these operators into a standard tabu search framework. We conduct extensive experiments on three main SDVRPs addressed in the literature: The basic SDVRP, the multidepot SDVRP, and the SDVRP with time windows. The experimental results show that the new forest-based solution representation is particularly effective in designing and implementing neighborhood operators, and that our new approach outperforms state-of-the-art algorithms on standard datasets.

关键词： vehicle routing multidepot time windows tabu search split delivery

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performance with high compression ratio based on knock suppression using Miller cycle with boost pressure and split

Haiqiao WEI, Jie YU, Lei ZHOU

《能源前沿（英文）》 2019年第13卷第4期页码 691-706 doi: 10.1007/s11708-019-0621-3

摘要： In theory, high compression ratio has the potential to improve the thermal efficiency and promote the power output of the SI engine. However, the application of high compression ratio is substantially limited by the knock in practical working process. The objective of this work is to comprehensively investigate the application of high compression ratio on a gasoline engine based on the Miller cycle with boost pressure and split injection. In this work, the specific optimum strategies for CR10 and CR12 were experimentally investigated respectively on a single cylinder DISI engine. It was found that a high level of Miller cycle with a higher boost pressure could be used in CR12 to achieve an effective compression ratio similar to CR10, which could eliminate the knock limits at a high compression ratio and high load. To verify the advantages of the high compression ratio, the fuel economy and power performance of CR10 and CR12 were compared at full and partial loads. The result revealed that, compared with CR10, a similar power performance and a reduced fuel consumption of CR12 at full load could be achieved by using the strong Miller cycle and split injection. At partial load, the conditions of CR12 had very superior fuel economy and power performance compared to those of CR10.

关键词： high compression ratio knock Miller cycle split injection engine performance

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Split-order consolidation optimization for online supermarkets: Process analysis and optimization models

《工程管理前沿（英文）》页码 499-516 doi: 10.1007/s42524-022-0221-5

摘要： The large-scale online supermarket is a newly emerging online retailing mode which brings great convenience to people. Online supermarkets are characterized by having large amounts of daily orders with potentially multiple items, diverse delivery times, and a high order-split rate. Multiple shipments for one order caused by order splitting result in high cost and disturbance and a large number of discarded consumable packages at online retailers and customers, causing severe damage to the environment. Accordingly, research on split-order consolidation fulfilment is critical for the advancement of the practice and theory in the context of highly complex online retailing. This paper first analyzes the characteristics and the challenges associated with the split-order consolidation problem that online supermarket is confronting and summarizes the new operational process of split-order consolidation fulfilment. Then, a time–space network optimization model is built, and its corresponding solution algorithm is presented to solve the questions of where and when to consolidate the split orders. Finally, the computation results of the numerical experiments are provided to verify the effectiveness of the algorithm, and a sensitivity analysis of the relevant parameters is performed. This work highlights the effect of order consolidation processes and fulfilment methods on the order fulfilment decision-making for online supermarkets. The purpose of this article is to help pave the way for more effective online supermarket management and order implementation.

关键词： online supermarkets split-order consolidation time–space network genetic algorithm

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Biodegradable polymethacrylic acid grafted psyllium for controlled drug delivery systems

Ranvijay KUMAR, Kaushlendra SHARMA

《化学科学与工程前沿（英文）》 2013年第7卷第1期页码 116-122 doi: 10.1007/s11705-013-1310-0

摘要： Polymethacrylic acid (PMA) was synthesized on the backbone of psyllium (Psy) by a microwave assisted method to prepare polymeric grafted materials designated as (Psy- -PMA). Various grades of Psy- -PMA were prepared by changing the degree of grafting from 35%–58% and the materials were then made into tablets. Swelling and biodegradability studies of the tablets were carried out. Acetyl salicylic acid was incorporated in the various Psy- -PMA samples and tablets were prepared to study the in vitro drug release in acidic (pH= 4), neutral (pH= 7), and basic (pH= 9) media. In the acidic medium, the swelling was more than 1300%. In addition, the biodegradable Psy- -PMA had the highest drug release in the acidic medium. This may be attributed to Fickian diffusion since the drug and the medium in which it was released have the same acidic nature.

关键词： psyllium acetyl salicylic acid in-vitro drug release swelling biodegradation

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Engineering platelet-mimicking drug delivery vehicles

Quanyin Hu, Hunter N. Bomba, Zhen Gu

《化学科学与工程前沿（英文）》 2017年第11卷第4期页码 624-632 doi: 10.1007/s11705-017-1614-6

摘要： Platelets dynamically participate in various physiological processes, including wound repair, bacterial clearance, immune response, and tumor metastasis. Recreating the specific biological features of platelets by mimicking the structure of the platelet or translocating the platelet membrane to synthetic particles holds great promise in disease treatment. This review highlights recent advancements made in the platelet-mimicking strategies. The future opportunities and translational challenges are also discussed.

关键词： drug delivery platelets nanomedicine bio-inspired biomimetic

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Gene delivery into isolated

Nan Zheng, Ziyuan Song, Yang Liu, Lichen Yin, Jianjun Cheng

《化学科学与工程前沿（英文）》 2017年第11卷第4期页码 521-528 doi: 10.1007/s11705-017-1612-8

摘要： The application of gene delivery materials has been mainly focused on mammalian cells while rarely extended to plant engineering. Cationic polymers and lipids have been widely utilized to efficiently deliver DNA and siRNA into mammalian cells. However, their application in plant cells is limited due to the different membrane structures and the presence of plant cell walls. In this study, we developed the cationic, -helical polypeptide that can effectively deliver DNA into both isolated protoplasts and intact leaves. The PPABLG was able to condense DNA to form nanocomplexes, and they exhibited significantly improved transfection efficiencies compared with commercial transfection reagent Lipofectamine 2000 and classical cell penetrating peptides such as poly(L-lysine), HIV-TAT, arginine9, and poly(L-arginine). This study therefore widens the utilities of helical polypeptide as a unique category of gene delivery materials, and may find their promising applications toward plant gene delivery.

关键词： α-helical polypeptide plant gene delivery protoplast intact leaves transfection

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Introduction to the special issue of the 2009 International Symposium on Crystal Engineering & Drug Delivery

Zhijian CHEN, Wei LI,

《化学科学与工程前沿（英文）》 2010年第4卷第1期页码 1-1 doi: 10.1007/s11705-009-0306-2

摘要：

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Controlled drug delivery systems: the next 30 years

Yeonhee YUN,Byung Kook LEE,Kinam PARK

《化学科学与工程前沿（英文）》 2014年第8卷第3期页码 276-279 doi: 10.1007/s11705-014-1426-x

摘要： The drug delivery scientists need to reexamine the advances made during the past 60 years, analyze our current abilities, and design the future technologies that will propel us to achieve the next level of drug delivery technologies. History shows that the first generation (1G) of drug delivery research during 1950–1980 was quite productive, while the second generation (2G) technologies developed during 1980–2010 were not as prolific. The ultimate goal of drug delivery research is to develop clinically useful formulations to treat various diseases. Effective drug delivery systems can be developed by overcoming formulation barriers and/or biological barriers. The engineering approach has a limit in solving the problem, if biological difficulties are not clearly identified and understood. The third generation (3G) drug delivery systems will have to focus on understanding the biological barriers so that they can be overcome by engineering manipulation of the drug delivery systems. Advances in the next 30 years will be most accelerated by starting open dialogues without any preconceived ideas on drug delivery technologies. The new generation of drug delivery scientists needs to be aware of the successes and limitations of the existing technologies to design the new technologies for meaningful advances in the future.

关键词： drug delivery history formulation barriers nanotechnology clinical product

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Bioorthogonal chemistry based on-demand drug delivery system in cancer therapy

《化学科学与工程前沿（英文）》 2023年第17卷第4期页码 483-489 doi: 10.1007/s11705-022-2227-2

摘要： Benefiting from the advantage of taking place in biological environments without interfering with an innate biochemical process, the bioorthogonal reaction that commonly contains the “bond formation” and “bond cleavage” system has been widely used in targeted therapy for a variety of tumors. Herein, several prominent cases based on the bioorthogonal reaction that tailoring the metabolic glycoengineering tactics to modified cells for cancer immunotherapy, and the innovative tactics for reducing the metal ions’ toxic and side effects with microneedle patches will be highlighted. Based on these applications, the complexities, potential pitfalls, and opportunities of bioorthogonal chemistry in future cancer therapy will be evaluated.

关键词： bioorthogonal reaction cancer therapy metabolic glycoengineering bioorthogonal catalytic patch

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Effect of the new maternity insurance scheme on medical expenditures for caesarean delivery in Wuxi,

null

《医学前沿（英文）》 2016年第10卷第4期页码 473-480 doi: 10.1007/s11684-016-0479-

摘要：

Aiming to control rising medical expenditures and help improve China’s healthcare systems, this study examined whether a cap-based medical insurance scheme with shared financial interest between the insurance and healthcare providers is effective in containing hospitals’ C-section medical expenditures. We used 6547 caesarean delivery case records from a teaching tertiary-level general public hospital located in Wuxi, China (2004–2013), and used the Chow test to investigate the possibility of significant variation in mean medical expenditures for caesarean deliveries pre- and post-reform. We also used paired sample t-tests and linear regression models to compare the mean medical expenditures between insured and uninsured women undergoing caesarean delivery during the post-reform period. After the scheme’s implementation, medical expenditures for caesarean deliveries declined and the medical expenditures of women covered by the scheme were significantly lower than those of uninsured patients. These findings indicated the scheme’s effectiveness in minimizing caesarean delivery expenditures. The cap-based medical insurance scheme with shared financial interest between insurance and healthcare providers would likely steer healthcare providers’ behaviors in a more cost-effective direction.

关键词： maternity insurance scheme financial incentive caesarean delivery medical expenditure China

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Economic analysis of a hybrid solar-fuel cell power delivery system using tuned genetic algorithm

Trina SOM, Niladri CHAKRABORTY

《能源前沿（英文）》 2012年第6卷第1期页码 12-20 doi: 10.1007/s11708-012-0172-3

摘要： An economic evaluation of a network of distributed energy resources (DERs) comprising a microgrid structure of power delivery system in an Indian scenario has been made. The mathematical analysis is based on the application of tuned genetic algorithm (TGA). The analyses for optimal power operation pertaining to minimum cost have been made for two cases in Indian power delivery system. The first case deals with the consumers’ individual optimal operation of DERs, while in the second one, consumers altogether form a microgrid with the optimal supply of power from DERs. The total annual costs for these two cases are found to be economically competitive and encouraging. A reduction of approximately 5.7% in the annual cost has been obtained in the case of microgid system than that in the separately operating consumers’ system for a small locality of India. It is observed that the application of TGA results in a reduction of the minimum cost depicting an improved outcome in terms of energy economy.

关键词： distributed energy resources (DERs) microgrid tuned genetic algorithm (TGA)

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Partial liver transplantation

null

《医学前沿（英文）》 2011年第5卷第1期页码 1-7 doi: 10.1007/s11684-010-0105-7

摘要：

Partial liver transplantation, including reduced-size liver transplantation, split liver transplantation, and living donor liver transplantation, has been developed with several innovative techniques because of donor shortage. Reduced-size liver transplantation is based on Couinaud’s anatomical classification, benefiting children and small adult recipients but failing to relieve the overall donor shortage. Split liver transplantation provides chances to two or even more recipients when only one liver graft is available. The splitting technique must follow stricter anatomical and physiological criteria either ex situ or in situto ensure long-term quality. The first and most important issue involving living donor liver transplantation is donor safety. Before surgery, a series of donor evaluations—including anatomical, liver volume, and liver function evaluations—is indispensable, followed by ethnic agreement. At different recipient conditions, auxiliary liver transplantation and auxiliary partial orthotopic liver transplantation, which employ piggyback techniques, are good alternatives. Partial liver transplantation enriches the practice and knowledge of the transplant society.

关键词： partial liver transplantation reduced-size liver transplantation split liver transplantation living donor liver transplantation

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海上风电场机组分体安装法及其应用

孙广喜,黄亚新

《中国工程科学》 2010年第12卷第11期页码 53-59

摘要：

对世界各国海上风电场的安装方法进行了归纳分类，分析风机海上分体安装法的工艺流程、装配基地设置的必要性和设置原则，归纳出8种典型的陆上组装方案及主要风机组件的装配工艺；提出一种海上风机潜水船坐底安装法：在潜水船上配置起重机构成风机潜水安装船，作业时潜水安装船潜入海底并坐落于海床，进行风机部件的吊装，该安装法适用于近海风电场建设；最后介绍了潜水船安装法在江苏响水近海风电场试验机组项目中的应用。

关键词：海上风电场陆上组装法分体安装法应用

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Zeolitic imidazolate framework-8 (ZIF-8) for drug delivery: A critical review

Simin Feng, Xiaoli Zhang, Dunyun Shi, Zheng Wang

《化学科学与工程前沿（英文）》 2021年第15卷第2期页码 221-237 doi: 10.1007/s11705-020-1927-8

摘要： Zeolitic imidazolate framework-8 (ZIF-8), composed of Zn ions and imidazolate ligands, is a class of metal-organic frameworks, which possesses a similar structure as conventional aluminosilicate zeolites. This material exhibits inherent porous property, high loading capacity, and pH-sensitive degradation, as well as exceptional thermal and chemical stability. Extensive research effort has been devoted to relevant research aspects ranging from synthesis methods, property characterization to potential applications of ZIF-8. This review focuses on the recent development of ZIF-8 synthesis methods and its promising applications in drug delivery. The potential risks of using ZIF-8 for drug delivery are also summarized.

关键词： zeolitic imidazolate framework-8 (ZIF-8) synthesis methods applications drug delivery

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A Double-Layer Polysaccharide Hydrogel (DPH) for the Enhanced Intestine-Targeted Oral Delivery of Probiotics

Wen-Can Huang,Wenjie Wang,Wei Wang,Yanan Hao,Changhu Xue,Xiangzhao Mao,

《工程（英文）》 doi: 10.1016/j.eng.2023.05.024

摘要： Transplantation of probiotics to the intestine can positively regulate the gut microbiota, thereby promoting the immune system and treating various diseases. However, the harsh gastrointestinal environment and short retention time in the gastrointestinal tract significantly limit the bioavailability and intestinal colonization of probiotics. Herein, we present a double-layer polysaccharide hydrogel (DPH) in the form of a double-layer structure composed of a carboxymethyl cellulose (CMCL) supramolecular inner layer and a dialdehyde alginate (DAA) cross-linked carboxymethyl chitosan (CMCS) outer layer. This double-layer structure allows DPH to encapsulate and deliver probiotics in a targeted manner within the body. In the stomach, the cage structure of the DPH is closed, and the outer layer absorbs surrounding liquids to form a barrier to protect the probiotics from gastric fluids. In the intestine, the cage structure opens and disintegrates, releasing the probiotics. Thus, DPH endows probiotics with excellent intestine-targeted delivery, improved oral bioavailability, enhanced gastrointestinal tract tolerance, and robust mucoadhesion capacity. The encapsulated probiotics exhibit almost unchanged bioactivity in the gastrointestinal tract before release, as well as improved oral delivery. In particular, probiotics encapsulated by DPH exhibit 100.1 times higher bioavailability and 10.6 times higher mucoadhesion than free probiotics in an animal model 48 h post-treatment. In addition, with a remarkable ability to survive and be retained in the intestine, probiotics encapsulated by DPH show excellent in vitro and in vivo competition with pathogens. Notably, DAA-mediated dynamic crosslinking not only maintains the overall integrity of the hydrogels but also controls the release timing of the probiotics. Thus, it is expected that encapsulated substances (probiotics, proteins, etc.) can be delivered to specific sites of the intestinal tract by means of DPH, by controlling the dynamic covalent crosslinking.

关键词： Polysaccharides Chitosan Hydrogels Oral delivery Intestine-targeted